Peptides can serve as versatile cancer-targeting ligands and have been used for clinically
relevant applications such as cancer imaging and therapy. A current and long-standing …

Inhibition of angiogenesis is an important strategy to block tumor growth and invasion. We
discuss herein results from our ongoing investigations on platelet factor-4 (PF-4) and the …

Modulating angiogenesis is an attractive goal because many pathological conditions
depend on the growth of new vessels. Angiogenesis is mainly regulated by the VEGF, a …

In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling
pathways contributing to angiogenic stimulation and tumor development. Characteristic …

The bone morphogenic protein antagonist gremlin is expressed during embryonic
development and under different pathologic conditions, including cancer. Gremlin is a …

Objective—The role of the nuclear receptor peroxisome-proliferator activated receptor
(PPAR)-β/δ in endothelial cells remains unclear. Interestingly, the selective PPARβ/δ ligand …

We report a two-color, cell-based screen to identify specific receptor-binding compounds in
a combinatorial library of peptoids displayed on beads. We apply this strategy to the …

Interleukin-8 (IL-8/CXCL8) is a chemokine that increases endothelial permeability during
early stages of angiogenesis. However, the mechanisms involved in IL-8/CXCL8-induced …

Constitutive activation of NF-κB is a frequent event in human cancers, playing important
roles in cancer development and progression. In nontransformed cells, NF-κB activation is …

Background The use of herbal plant extracts in wound healing is known through decades,
but it is necessary to provide scientific data through reverse pharmacology. Objective The …