The non-attached biofilm aggregate

KN Kragh, T Tolker-Nielsen, M Lichtenberg - Communications Biology, 2023 - nature.com
Biofilms have conventionally been perceived as dense bacterial masses on surfaces,
following the five-step model of development. Initial biofilm research focused on surface …

Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds

G Schultz, T Bjarnsholt, GA James… - Wound Repair and …, 2017 - Wiley Online Library
Background: Despite a growing consensus that biofilms contribute to a delay in the healing
of chronic wounds, conflicting evidence pertaining to their identification and management …

Pseudomonas aeruginosa Biofilms in Disease

LR Mulcahy, VM Isabella, K Lewis - Microbial ecology, 2014 - Springer
Pseudomonas aeruginosa is a ubiquitous organism that is the focus of intense research
because of its prominent role in disease. Due to its relatively large genome and flexible …

Applying insights from biofilm biology to drug development—can a new approach be developed?

T Bjarnsholt, O Ciofu, S Molin, M Givskov… - Nature reviews Drug …, 2013 - nature.com
Most of the research on bacterial pathogenesis has focused on acute infections, but much
less is known about the pathogenesis of infections caused by bacteria that grow as …

Supramolecular assemblies of heterogeneous mesoporous silica nanoparticles to co-deliver antimicrobial peptides and antibiotics for synergistic eradication of …

Q Yu, T Deng, FC Lin, B Zhang, JI Zink - Acs Nano, 2020 - ACS Publications
Pathogenic biofilms protected by extracellular polymeric substances frequently compromise
the efficiency of antibacterial drugs and severely threaten human health. In this study, we …

Propionibacterium acnes: from commensal to opportunistic biofilm-associated implant pathogen

Y Achermann, EJC Goldstein, T Coenye… - Clinical microbiology …, 2014 - Am Soc Microbiol
Propionibacterium acnes is known primarily as a skin commensal. However, it can present
as an opportunistic pathogen via bacterial seeding to cause invasive infections such as …

Pseudomonas aeruginosa biofilm infections: community structure, antimicrobial tolerance and immune response

M Rybtke, LD Hultqvist, M Givskov… - Journal of molecular …, 2015 - Elsevier
Studies of biopsies from infectious sites, explanted tissue and medical devises have
provided evidence that biofilms are the underlying cause of a variety of tissue-associated …

Pseudomonas aeruginosa biofilms: mechanisms of immune evasion

M Alhede, T Bjarnsholt, M Givskov, M Alhede - Advances in applied …, 2014 - Elsevier
The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many
chronic infections and is readily isolated from chronic wounds, medical devices, and the …

Biofilms and host response–helpful or harmful

C Moser, HT Pedersen, CJ Lerche, M Kolpen, L Line… - Apmis, 2017 - Wiley Online Library
Biofilm infections are one of the modern medical world's greatest challenges. Probably, all
non‐obligate intracellular bacteria and fungi can establish biofilms. In addition, there are …

Extracellular DNA-induced antimicrobial peptide resistance mechanisms in Pseudomonas aeruginosa

S Lewenza - Frontiers in microbiology, 2013 - frontiersin.org
Extracellular DNA (eDNA) is in the environment, bodily fluids, in the matrix of biofilms, and
accumulates at infection sites. eDNA can function as a nutrient source, a universal biofilm …