Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated
effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema …

The cranial neural crest generates a huge diversity of derivatives, including the bulk of
connective and skeletal tissues of the vertebrate head. How neural crest cells acquire such …

Abstract Knowledge of the early evolution of fish largely depends on soft-bodied material
from the Lower (Series 2) Cambrian period of South China 1, 2. Owing to the rarity of some …

Despite the importance of tendons and ligaments for transmitting movement and providing
stability to the musculoskeletal system, their development is considerably less well …

The craniofacial skeletal structures that comprise the human head develop from multiple
tissues that converge to form the bones and cartilage of the face. Because of their complex …

Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the
embryonic pharyngeal arches. How complex signaling information is integrated to specify …

We present a gene expression atlas of early mouse craniofacial development. Laser capture
microdissection (LCM) was used to isolate cells from the principal critical microregions …

The intricate shaping of the facial skeleton is essential for function of the vertebrate jaw and
middle ear. While much has been learned about the signaling pathways and transcription …