Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

The TSH receptor (TSHR) together with the homologous lutropin/choriogonadotropin
receptor and the follitropin receptor are glycoprotein hormone receptors (GPHRs). They …

Consanguinity is the blood relationship that exists among individuals that descend from a
common ancestor. The objectives of the study was to explore the frequency and socio …

Thyroperoxidase-catalyzed iodination of thyroglobulin and subsequent oxidative coupling of
iodinated tyrosyl residues to protein-bound iodothyronines are the key reactions in thyroid …

Context: In the human thyroid gland, TSH activates both the cAMP and inositol phosphates
(IP) signaling cascades via binding to the TSH receptor (TSHR). Biallelic TSHR loss-of …

This chapter presents an analysis and a summarized synthesis of our present knowledge of
the biology of the thyroid gland, phylogeny, ontogeny, anatomy, structure, general …

Inositols, a group of 6-carbon polyols, are highly bioactive molecules derived from diet and
endogenous synthesis. Inositols and their derivatives are involved in glucose and lipid …

In this study we wanted to gain insights into selectivity mechanisms between G-protein-
coupled receptors (GPCR) and different subtypes of G-proteins. The thyrotropin receptor …

Gonadotropin signaling plays an indispensable role in ovarian cancer progression. We
previously have demonstrated that thyrostimulin and thyroid-stimulating hormone receptor …

The thyroid-stimulating hormone receptor (TSHR, or thyrotropin receptor) is a family AG
protein-coupled receptor. It not only binds thyroid-stimulating hormone (TSH, or thyrotropin) …