IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …

Both observational and interventional studies suggest an important role for physical activity
and higher fitness in mitigating the metabolic syndrome. Each component of the metabolic …

It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …

Background Authors were assigned the task to develop case definitions for periodontitis in
the context of the 2017 World Workshop on the Classification of Periodontal and Peri …

C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at
sites of infection or inflammation. CRP is produced as a homopentameric protein, termed …

Diverticulitis is a prevalent gastrointestinal disorder that is associated with significant
morbidity and health care costs. Approximately 20% of patients with incident diverticulitis …

Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …