The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Inflammation is an important process involved in several cardiovascular diseases (CVDs),
and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital …

Background: Sterile inflammation resulting from myocardial injury activates the NLRP3
inflammasome and amplifies the inflammatory response mediating further damage …

Human samples of patients with chronic pericarditis and appropriate control subjects were
stained for the inflammasome components. A mouse model of pericarditis was developed …

Background: Activation of the NLRP3 inflammasome is a primary driver of sterile
inflammation in response to myocardial ischemia reperfusion. Pharmacologic inhibitors of …

Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the
respiratory and motor functions of patients, thus severely impacting their quality of life and …

Significance: An inflammatory response follows an injury of any nature, and while such a
response is an attempt to promote healing, it may, itself, result in further injury. Recent …

Ischemia‐reperfusion (I/R) injury is one of the major causes of high morbidity, disability, and
mortality in the world. I/R injury remains a complicated and unresolved situation in clinical …

Although the nucleotide‐binding oligomerization domain‐(NOD‐) like receptor pyrin domain
containing 3 (NLRP3) inflammasome has been recently detected in the heart, its role in …