Dry eye disease (DED) affects up to one-third of the global population. Traditional therapies,
including topical lubricants, have been employed with variable success in the treatment of …

Neuromodulation is a novel approach that utilizes electrical signals, pharmaceutical agents,
or other forms of energy to modulate abnormal neural function through neurostimulation …

Purpose: The purpose of this trial was to evaluate the safety and efficacy of OC-01
(varenicline solution), a nicotinic acetylcholine receptor agonist nasal spray, on signs and …

Purpose Dry eye disease is characterized by loss of tear film stability. OC-01 (varenicline
solution) is a small-molecule nicotinic acetylcholine receptor agonist administered as a …

Purpose: To evaluate the efficacy and safety of iTEAR, a novel, portable, sonic external
neuromodulation device, for the treatment of dry eye disease (DED). Methods: This was a …

Purpose The intranasal tear neurostimulator (ITN) activates the nasolacrimal pathway, which
is involved with basal and bolus tear secretion. These studies characterized the acute and …

Tear secretion is regulated by the lacrimal functional unit consisting of afferent and efferent
nerve innervation. The afferent arm consists of trigeminal nociceptors on the ocular surface …

ABSTRACT Introduction Dry Eye Disease (DED) is defined as a multifactorial disease of the
ocular surface characterized by a loss of homeostasis of the tear film, and a vicious cycle of …

Purpose To evaluate the safety and effectiveness of the intranasal tear neurostimulator (ITN)
in improving dry eye symptoms assessed in a controlled adverse environment (CAE®) …

Introduction To assess the effectiveness and safety of intranasal tear neurostimulation in the
treatment of dry eye disease. Methods We performed a meta-analysis of four databases from …