[HTML][HTML] Recent advances in sensing the inter-biomolecular interactions at the nanoscale–A comprehensive review of AFM-based force spectroscopy
Biomolecular interactions underpin most processes inside the cell. Hence, a precise and
quantitative understanding of molecular association and dissociation events is crucial, not …
quantitative understanding of molecular association and dissociation events is crucial, not …
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level
Protein-protein and protein-RNA interactions are essential for cell function and survival.
These interactions facilitate the formation of ribonucleoprotein complexes and biomolecular …
These interactions facilitate the formation of ribonucleoprotein complexes and biomolecular …
Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles
Abstract SARS‐CoV‐2 spike protein (S) binds to human angiotensin‐converting enzyme 2
(hACE2), allowing virus to dock on cell membrane follow by viral entry. Here, we use high …
(hACE2), allowing virus to dock on cell membrane follow by viral entry. Here, we use high …
Real-time multistep asymmetrical disassembly of nucleosomes and chromatosomes visualized by high-speed atomic force microscopy
B Onoa, C Díaz-Celis, C Cañari-Chumpitaz… - ACS Central …, 2023 - ACS Publications
During replication, expression, and repair of the eukaryotic genome, cellular machinery must
access the DNA wrapped around histone proteins forming nucleosomes. These octameric …
access the DNA wrapped around histone proteins forming nucleosomes. These octameric …
[HTML][HTML] How SARS-CoV-2 and other viruses build an invasion route to hijack the host nucleocytoplasmic trafficking system
ES Sajidah, K Lim, RW Wong - Cells, 2021 - mdpi.com
The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish
their replication and to suppress the host immune response. Viruses encode many factors …
their replication and to suppress the host immune response. Viruses encode many factors …
Nanoscopic Assessment of Anti-SARS-CoV-2 Spike Neutralizing Antibody Using High-Speed AFM
Anti-spike neutralizing antibodies (S NAbs) have been developed for prevention and
treatment against COVID-19. The nanoscopic characterization of the dynamic interaction …
treatment against COVID-19. The nanoscopic characterization of the dynamic interaction …
Spatiotemporal tracking of small extracellular vesicle nanotopology in response to physicochemical stresses revealed by HS‐AFM
Small extracellular vesicles (sEVs) play a crucial role in local and distant cell
communication. The intrinsic properties of sEVs make them compatible biomaterials for drug …
communication. The intrinsic properties of sEVs make them compatible biomaterials for drug …
[HTML][HTML] New activities of the nuclear pore complexes
RW Wong - Cells, 2021 - mdpi.com
Nuclear pore complexes (NPCs) at the surface of nuclear membranes play a critical role in
regulating the transport of both small molecules and macromolecules between the cell …
regulating the transport of both small molecules and macromolecules between the cell …
Real-time single-molecule observation of incipient collagen fibrillogenesis and remodeling
J Roth, C Hoop, JK Williams, V Nanda… - Proceedings of the …, 2024 - pnas.org
The hierarchic assembly of fibrillar collagen into an extensive and ordered supramolecular
protein fibril is critical for extracellular matrix function and tissue mechanics. Despite …
protein fibril is critical for extracellular matrix function and tissue mechanics. Despite …
Nanoscopic Elucidation of Spontaneous Self-Assembly of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Open Reading Frame 6 (ORF6) Protein
Open reading frame 6 (ORF6), the accessory protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) that suppresses host type-I interferon signaling, possesses …
coronavirus 2 (SARS-CoV-2) that suppresses host type-I interferon signaling, possesses …