Genome-wide association studies have greatly improved our understanding of the genetic
basis of disease risk. The fact that they tend not to identify more than a fraction of the specific …

Abstract Systems genetics is an approach to understand the flow of biological information
that underlies complex traits. It uses a range of experimental and statistical methods to …

Abstract The Collaborative Cross Consortium reports here on the development of a unique
genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …

Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …

The mammalian gut harbors complex and variable microbial communities, across both host
phylogenetic space and conspecific individuals. A synergy of host genetic and …

The February 2012 issues of GENETICS and G3: Genes, Genomes, Genetics present a
collection of articles reporting recent advances from the international Collaborative Cross …

Genome-wide association studies (GWASs) have transformed the field of human genetics
and have led to the discovery of hundreds of genes that are implicated in human disease …

Genetic dissection of complex, polygenic trait variation is a key goal of medical and
evolutionary genetics. Attempts to identify genetic variants underlying complex traits have …