The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

It has been known for decades that it is possible to detect small amounts of extracellular
nucleic acids in plasma and serum of healthy and diseased human beings. The unequivocal …

Purpose: The purpose of this study was to directly compare mutation profiles in multiple
single circulating tumor cells (CTC) and cell-free DNA (cfDNA) isolated from the same blood …

Although it is evident that DNA circulates freely in blood plasma both in disease and in
health, the source of this DNA remains enigmatic. It can be presumed that circulating DNA in …

Objective To provide an introduction to the concept of DNA methylation and its function in
normal cells, and to explain the possible mechanisms as to how abnormalities in this …

We evaluated whether the amount of circulating DNA in plasma could discriminate between
lung cancer patients and healthy individuals and whether it is related to disease …

Promoter hypermethylation is an important pathway for repression of gene transcription in
cancer cells. We analyzed aberrant DNA methylation at four genes in primary tumors from …

Surface-enhanced Raman scattering (SERS) is an ultrasensitive molecular screening
technique with greatly enhanced Raman scattering signals from trace amounts of analytes …

Digital PCR represents an example of the power of PCR and provides unprecedented
opportunities for molecular genetic analysis in cancer. The technique is to amplify a single …