While red blood cell (RBC) transfusion is the most common medical intervention in
hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure …

The first 1,000 days in the life of a human being are a vulnerable stage where early stimuli
may program adverse health outcomes in future life. Proper maternal nutrition before and …

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG
antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate …

Passive immunization with anti-D can prevent maternal alloimmunization to RhD thereby
preventing hemolytic disease of the fetus and newborn. Unexpectedly, anti-D fails in some …

Administration of anti-RhD immunoglobulin (Ig) to decrease maternal alloimmunization
(antibody-mediated immune suppression [AMIS]) was a landmark clinical development …

Pregnancy has fascinated immunologists ever since Peter Medawar's observation that
reproduction runs contrary to the founding tenets of immunology. During healthy pregnancy …

Post-transfusion alloimmunisation is the main complication of all those observed after one or
more transfusion episodes. Alloimmunisation is observed after the transfusion of red blood …

Red blood cells expressing alloantigens are well known to be capable of inducing robust
humoral alloantibody responses both in transfusion and pregnancy. However, the majority of …

In this review we aim to summarize the current state of methods for label-free identification
and functional characterization of leukocytes with biosensors and novel single cell …

Background The administration of anti‐D for the prevention of hemolytic disease of the fetus
and newborn is one of the most successful clinical uses of the phenomenon of antibody …