The sleep-immune crosstalk in health and disease

L Besedovsky, T Lange, M Haack - Physiological reviews, 2019 - journals.physiology.org
Sleep-immune interactions are well-known phenomena in everyday life and folk wisdom.
There is no doubt that an infection makes us tired and increases the desire to sleep, and a …

Genetics of rheumatoid arthritis

L Padyukov - Seminars in immunopathology, 2022 - Springer
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …

Pathogenetic insights from the treatment of rheumatoid arthritis

IB McInnes, G Schett - The Lancet, 2017 - thelancet.com
Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular
damage, functional loss, and comorbidity. The development of effective biologics and small …

Immunopathogenesis of rheumatoid arthritis

GS Firestein, IB McInnes - Immunity, 2017 - cell.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

Intestinal dysbiosis and rheumatoid arthritis: a link between gut microbiota and the pathogenesis of rheumatoid arthritis

G Horta-Baas, MS Romero-Figueroa… - Journal of …, 2017 - Wiley Online Library
Characterization and understanding of gut microbiota has recently increased representing a
wide research field, especially in autoimmune diseases. Gut microbiota is the major source …

CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-κB axis

J Yang, M Cheng, B Gu, J Wang, S Yan, D Xu - Cell death & disease, 2020 - nature.com
A number of circular RNAs (circRNAs) have been implicated in rheumatoid arthritis (RA)
pathogenesis; however, little is known about their function and hidden molecular …

Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology

M Volkov, KA van Schie… - Immunological …, 2020 - Wiley Online Library
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In
the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly …

Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities

K Yuan, Q Zhu, Q Lu, H Jiang, M Zhu, X Li… - The Journal of nutritional …, 2020 - Elsevier
Rheumatoid arthritis (RA) is a prototypical autoimmune disorder mainly characterized by
joint inflammation and cartilage destruction. Neutrophils actively take part in the initiation …

Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

P Holmstrup, C Damgaard, I Olsen… - Journal of oral …, 2017 - Taylor & Francis
Increasing evidence has suggested an independent association between periodontitis and
a range of comorbidities, for example cardiovascular disease, type 2 diabetes, rheumatoid …

The potential role of trained immunity in autoimmune and autoinflammatory disorders

RJW Arts, LAB Joosten, MG Netea - Frontiers in immunology, 2018 - frontiersin.org
During induction of trained immunity, monocytes and macrophages undergo a functional
and transcriptional reprogramming toward increased activation. Important rewiring of cellular …