A second space age spanning omics, platforms and medicine across orbits
The recent acceleration of commercial, private and multi-national spaceflight has created an
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …
[PDF][PDF] Protective alleles and precision healthcare in crewed spaceflight
Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …
omics technologies are increasingly being used to develop health and treatment …
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …
myriad biomedical challenges to the human body, which are becoming increasingly relevant …
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight
Maintenance of astronaut health during spaceflight will require monitoring and potentially
modulating their microbiomes. However, documenting microbial shifts during spaceflight has …
modulating their microbiomes. However, documenting microbial shifts during spaceflight has …
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
As spaceflight becomes more common with commercial crews, blood-based measures of
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
crew health can guide both astronaut biomedicine and countermeasures. By profiling …
Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses
The advent of civilian spaceflight challenges scientists to precisely describe the effects of
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …
Spaceflight induces changes in gene expression profiles linked to insulin and estrogen
Organismal adaptations to spaceflight have been characterized at the molecular level in
model organisms, including Drosophila and C. elegans. Here, we extend molecular work to …
model organisms, including Drosophila and C. elegans. Here, we extend molecular work to …
Spatiotemporal expression and control of haemoglobin in space
It is now widely recognised that the environment in space activates a diverse set of genes
involved in regulating fundamental cellular pathways. This includes the activation of genes …
involved in regulating fundamental cellular pathways. This includes the activation of genes …
Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight
JS Garcia-Medina, K Sienkiewicz… - Precision Clinical …, 2024 - academic.oup.com
Abstract Background The Inspiration4 (I4) mission, the first all-civilian orbital flight mission,
investigated the physiological effects of short-duration spaceflight through a multi-omic …
investigated the physiological effects of short-duration spaceflight through a multi-omic …