Covalent organic frameworks for biomedical applications

A Esrafili, A Wagner, S Inamdar… - Advanced Healthcare …, 2021 - Wiley Online Library
Covalent organic frameworks (COFs) are porous organic polymeric materials that are
composed of organic elements and linked together by the thermodynamically stable …

Poly (disulfide) s: from synthesis to drug delivery

R Zhang, T Nie, Y Fang, H Huang, J Wu - Biomacromolecules, 2021 - ACS Publications
Bioresponsive polymers have been widely used in drug delivery because of their
degradability. For example, poly (disulfide) s with repeating disulfide bonds in the main …

A review of the tortuous path of nonviral gene delivery and recent progress

D Sharma, S Arora, J Singh, B Layek - International journal of biological …, 2021 - Elsevier
Gene therapy encompasses the transfer of exogenous genetic materials into the patient's
target cells to treat or prevent diseases. Nevertheless, the transfer of genetic material into …

Corneal gene therapy: structural and mechanistic understanding

R Kumar, NR Sinha, RR Mohan - The Ocular Surface, 2023 - Elsevier
Cornea, a dome-shaped and transparent front part of the eye, affords 2/3rd refraction and
barrier functions. Globally, corneal diseases are the leading cause of vision impairment …

Anti-angiogenesis and anti-immunosuppression gene therapy through targeting COUP-TFII in an in situ glioblastoma mouse model

F Wang, S Zhang, F Sun, W Chen, C Liu, H Dong… - Cancer gene …, 2024 - nature.com
Glioblastoma (GBM) is the most common and aggressive primary brain cancer;
angiogenesis and immunosuppression exacerbate GBM progression. COUP-TFII …

Click-functionalized hydrogel design for mechanobiology investigations

E Hui, JL Sumey, SR Caliari - Molecular systems design & …, 2021 - pubs.rsc.org
The advancement of click-functionalized hydrogels in recent years has coincided with rapid
growth in the fields of mechanobiology, tissue engineering, and regenerative medicine …

Guanidinium-rich lipopeptide-based nanoparticle enables efficient gene editing in skeletal muscles

M Zhu, X Wang, R Xie, Y Wang, X Xu… - … Applied Materials & …, 2023 - ACS Publications
Genome editing mediated by the CRISPR-Cas system holds great promise for the treatment
of genetic diseases. However, safe and efficient in vivo delivery of CRISPR genome editing …

Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli

K Muhammad, J Zhao, B Gao, Y Feng - Journal of Materials Chemistry …, 2020 - pubs.rsc.org
Polymeric nano-carriers have been developed as a most capable and feasible technology
platform for gene therapy. As vehicles, polymeric nano-carriers are obliged to possess high …

Well-defined pH-responsive self-assembled block copolymers for the effective codelivery of doxorubicin and antisense oligonucleotide to breast cancer cells

MA Mohamed, L Yan, A Shahini… - ACS Applied Bio …, 2022 - ACS Publications
The worldwide steady increase in the number of cancer patients motivates the development
of innovative drug delivery systems for combination therapy as an effective clinical modality …

Green synthesis of carbon quantum dots from food waste

E Dhandapani, N Duraisamy, RM Raj - Materials Today: Proceedings, 2022 - Elsevier
A highly green fluorescent carbon quantum dots (CQDs) synthesized from food waste via
one step green synthesis. As-synthesized colloidal CQDs are highly stable due to their …