DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …

Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is
clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and …

Background Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory
disease characterized by destructive systemic organ involvement, which could cause the …

Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …

Autoimmune diseases are usually complex and multifactorial, characterized by aberrant
production of autoreactive immune cells and/or autoantibodies against healthy cells and …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Epigenetic mechanisms, namely DNA and histone modifications, are critical regulators of
immunity and inflammation which have emerged as potential targets for immunomodulating …

Cutaneous lupus erythematosus (CLE) is an inflammatory, autoimmune disease
encompassing a broad spectrum of subtypes including acute, subacute, chronic and …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominately
affects women. It is characterised by a broad spectrum of clinical manifestations, however, its …

Cellular intrinsic immunity, mediated by the expression of an array of interferon-stimulated
antiviral genes, is a vital part of host defense. We have previously used a bioinformatic …