Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between …
ECM de Lange, M Danhof - Clinical pharmacokinetics, 2002 - Springer
In the clinical setting, drug concentrations in cerebrospinal fluid (CSF) are sometimes used
as a surrogate for drug concentrations at the target site within the brain. However, the brain …
as a surrogate for drug concentrations at the target site within the brain. However, the brain …
Expression and function of cytochrome p450 in brain drug metabolism
RP Meyer, M Gehlhaus, R Knoth… - Current drug …, 2007 - ingentaconnect.com
Cytochrome P450 (CYP, P450) is the collective term for a superfamily of heme-containing
membrane proteins responsible for the metabolism of∼ 70-80% of clinically used drugs …
membrane proteins responsible for the metabolism of∼ 70-80% of clinically used drugs …
Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole
G Schwartz, MG Fehlings - Journal of Neurosurgery: Spine, 2001 - thejns.org
Object. Persistent activation of voltage-sensitive Na+ channels is associated with cellular
toxicity and may contribute to the degeneration of neural tissue following traumatic brain and …
toxicity and may contribute to the degeneration of neural tissue following traumatic brain and …
Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat
HC Doheny, N Ratnaraj, MA Whittington, JGR Jefferys… - Epilepsy research, 1999 - Elsevier
The temporal pharmacokinetic interrelationship of levetiracetam in blood and cerebrospinal
fluid (CSF) was studied after acute intraperitoneal administration of levetiracetam (20, 40 …
fluid (CSF) was studied after acute intraperitoneal administration of levetiracetam (20, 40 …
Comparison of serum, cerebrospinal fluid and brain extracellular fluid pharmacokinetics of lamotrigine
MC Walker, X Tong, H Perry… - British journal of …, 2000 - Wiley Online Library
We investigated the rate of penetration into and the intra‐relationship between the serum,
cerebrospinal fluid (CSF) and regional brain extracellular fluid (bECF) compartments …
cerebrospinal fluid (CSF) and regional brain extracellular fluid (bECF) compartments …
Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model
JJ Luszczki, N Ratnaraj, PN Patsalos… - … archives of pharmacology, 2006 - Springer
This study examined the interaction characteristics between loreclezole (LCZ) and various
conventional antiepileptic drugs (phenytoin-PHT, carbamazepine-CBZ, valproate-VPA and …
conventional antiepileptic drugs (phenytoin-PHT, carbamazepine-CBZ, valproate-VPA and …
Chronic administration of phenytoin induces efflux transporter overexpression in rats
S Alvariza, P Fagiolino, M Vázquez… - Pharmacological …, 2014 - Elsevier
Background Efflux transporters overexpression has been proposed as one of the
responsible mechanism for refractory epilepsy by preventing access of the antiepileptic drug …
responsible mechanism for refractory epilepsy by preventing access of the antiepileptic drug …
Noninvasive transcranial focal stimulation affects the convulsive seizure-induced P-glycoprotein expression and function in rats
D Pérez-Pérez, JL Castañeda-Cabral… - Epilepsy & Behavior, 2021 - Elsevier
Transcranial focal stimulation (TFS) is a noninvasive neuromodulation strategy that reduces
seizure activity in different experimental models. Nevertheless, there is no information about …
seizure activity in different experimental models. Nevertheless, there is no information about …
Comparison of single‐and repeated‐dose pharmacokinetics of diazepam
MC Walker, X Tong, S Brown, SD Shorvon… - …, 1998 - Wiley Online Library
Purpose: To determine whether repeat boluses of diazepam (DZP) lead to significant
accumulation in the central nervous system and/or peripheral compartments, as repeat …
accumulation in the central nervous system and/or peripheral compartments, as repeat …
Effects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving rats
S Ahmad, LJ Fowler, PS Whitton - Naunyn-Schmiedeberg's archives of …, 2005 - Springer
The antiepileptic drugs sodium valproate (VPA) and lamotrigine (LTG) are increasingly used
in combination in patients in whom monotherapy has failed to control seizures. Although …
in combination in patients in whom monotherapy has failed to control seizures. Although …