The advent of genome editing has transformed the therapeutic landscape for several debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties of solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It is a multi …
Nanoparticles as drug delivery system have received much attention in recent years, especially for cancer treatment. In addition to improving the pharmacokinetics of the loaded …
X Ren, Y Feng, J Guo, H Wang, Q Li, J Yang… - Chemical Society …, 2015 - pubs.rsc.org
Surface modification and endothelialization of vascular biomaterials are common approaches that are used to both resist the nonspecific adhesion of proteins and improve …
H Tian, Z Tang, X Zhuang, X Chen, X Jing - Progress in Polymer Science, 2012 - Elsevier
Biodegradable polymers have been widely used and have greatly promoted the development of biomedical fields because of their biocompatibility and biodegradability. The …
Polymeric micelles, self-assembling nano-constructs of amphiphilic copolymers with a core- shell structure have been used as versatile carriers for delivery of drugs as well as nucleic …
In the 10 years that have passed since the Nobel prize-winning discovery of RNA interference (RNAi), billions of dollars have been invested in the therapeutic application of …
AME Abdalla, L Xiao, MW Ullah, M Yu, C Ouyang… - Theranostics, 2018 - ncbi.nlm.nih.gov
With growing interest in cancer therapeutics, anti-angiogenic therapy has received considerable attention and is widely administered in several types of human cancers …