Metagenomic sequence analysis is rapidly becoming the primary source of virus discovery,–
. A substantial majority of the currently available virus genomes come from metagenomics …

The MEME Suite is a powerful, integrated set of web-based tools for studying sequence
motifs in proteins, DNA and RNA. Such motifs encode many biological functions, and their …

The origin of life is believed to have progressed through an RNA world, in which RNA acted
as both genetic material and functional molecules. The structure of the evolutionary fitness …

Strong evidence supports the idea that fatty acids rather than carbohydrates are the main
energy source of Mycobacterium tuberculosis during infection and latency. Despite that …

An important antibiotic target, DNA gyrase is an essential bacterial enzyme that introduces
negative supercoils into DNA and relaxes positive supercoils accumulating in front of …

Peptides are extensively used to characterize functional or (linear) structural aspects of
receptor–ligand interactions in biological systems, eg SH2, SH3, PDZ peptide-recognition …

The transcriptome describes the expression of all genes in a sample. Most studies have
investigated the differential patterns or discrimination powers of transcript expression levels …

The pervasive transcription of the genome creates many types of non-coding RNAs
(ncRNAs). However, we know very little regarding the functions and the regulatory …

Zinc is a bivalent cation essential for bacterial growth and metabolism. The human pathogen
Neisseria meningitidis expresses a homologue of the Zinc uptake regulator Zur, which has …

Motivation: A number of techniques exist for the detection of short, subtle conserved regions
within DNA and amino acid sequences. The purpose of this overview is to present the ideas …