The epigenetic hallmarks of cancer
M Esteller, MA Dawson, C Kadoch, FV Rassool… - Cancer …, 2024 - aacrjournals.org
Cancer is a complex disease in which several molecular and cellular pathways converge to
foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks,“ …
foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks,“ …
[HTML][HTML] Chromatin remodeling and spatial concerns in DNA double-strand break repair
JA Downs, SM Gasser - Current Opinion in Cell Biology, 2024 - Elsevier
The substrate for the repair of DNA damage in living cells is not DNA but chromatin.
Chromatin bears a range of modifications, which in turn bind ligands that compact or open …
Chromatin bears a range of modifications, which in turn bind ligands that compact or open …
PHF6-altered T-ALL Harbor Epigenetic Repressive Switch at Bivalent Promoters and Respond to 5-Azacitidine and Venetoclax
A Pinton, L Courtois, C Doublet… - Clinical Cancer …, 2024 - AACR
Purpose: To assess the impact of PHF6 alterations on clinical outcome and therapeutical
actionability in T-cell acute lymphoblastic leukemia (T-ALL). Experimental Design: We …
actionability in T-cell acute lymphoblastic leukemia (T-ALL). Experimental Design: We …
PHF6 suppresses self-renewal of leukemic stem cells in AML
SS Jalnapurkar, AS Pawar, SS George, C Antony… - Leukemia, 2024 - nature.com
Acute myeloid leukemia is characterized by uncontrolled proliferation of self-renewing
myeloid progenitors accompanied by a differentiation arrest. PHF6 is a chromatin-binding …
myeloid progenitors accompanied by a differentiation arrest. PHF6 is a chromatin-binding …
Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson–Forssman–Lehmann …
HM McRae, MPY Leong, MI Bergamasco… - PLoS …, 2024 - journals.plos.org
Börjeson-Forssman-Lehmann syndrome (BFLS) is an X-linked intellectual disability and
endocrine disorder caused by pathogenic variants of plant homeodomain finger gene 6 …
endocrine disorder caused by pathogenic variants of plant homeodomain finger gene 6 …
Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting
Y Kubota, X Gu, L Terkawi, J Bodo… - Nature …, 2024 - nature.com
Abstract PHF6 mutations (PHF6 MT) are identified in various myeloid neoplasms (MN).
However, little is known about the precise function and consequences of PHF6 in MN. Here …
However, little is known about the precise function and consequences of PHF6 in MN. Here …
CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly
H Schwaemmle, H Soldati, NMR Lykoskoufis… - bioRxiv, 2024 - biorxiv.org
The SWI/SNF (or BAF) complex is an essential chromatin remodeler that regulates DNA
accessibility at developmental genes and enhancers. SWI/SNF subunits are among the most …
accessibility at developmental genes and enhancers. SWI/SNF subunits are among the most …
[HTML][HTML] Visualizing DNA replication by single-molecule analysis of replicated DNA
A Madireddy, J Gerhardt - STAR protocols, 2023 - Elsevier
Single-molecule analysis of replicated DNA (SMARD) is a unique technique that enables
visualization of DNA replication at specific genomic regions at single-molecule resolution …
visualization of DNA replication at specific genomic regions at single-molecule resolution …
Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses myeloid leukemia stemness
AS Pawar, P Somers, A Alex, SS George, C Antony… - bioRxiv, 2024 - biorxiv.org
Myeloid leukemias are heterogeneous cancers with a diverse mutational landscape.
Though many mutated genes fall within common protein complexes, some lack known …
Though many mutated genes fall within common protein complexes, some lack known …
The chromatin reader PHF6 at the crossroad of the replication stress and DNA damage responses in neuroblastoma through interaction with RRM2
L Depestel, E Sanders, SL Bekaert, C Van Damme… - bioRxiv, 2023 - biorxiv.org
The 'plant homeodomain zinc finger protein 6'(PHF6) is affected by germline mutations in
patients with cognitive disabilities and somatic mutations in acute T-cell leukemia (T-ALL) …
patients with cognitive disabilities and somatic mutations in acute T-cell leukemia (T-ALL) …