The SMC5/6 complex: folding chromosomes back into shape when genomes take a break
S Roy, H Adhikary, D D'Amours - Nucleic Acids Research, 2024 - academic.oup.com
High-level folding of chromatin is a key determinant of the shape and functional state of
chromosomes. During cell division, structural maintenance of chromosome (SMC) …
chromosomes. During cell division, structural maintenance of chromosome (SMC) …
Poly (ADP-Ribose) Polymerase Inhibition as a Promising Approach for Hepatocellular Carcinoma Therapy
A Paturel, J Hall, I Chemin - Cancers, 2022 - mdpi.com
Simple Summary Liver cancer has very high incidence and mortality rates, making it a major
public health problem. Indeed, the available treatments are not numerous, and few …
public health problem. Indeed, the available treatments are not numerous, and few …
The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2
S Roy, H Adhikary, S Isler, D D'Amours - eLife, 2024 - elifesciences.org
The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex
joined to a displaced strand of genomic DNA. While the effects of R-loops on health and …
joined to a displaced strand of genomic DNA. While the effects of R-loops on health and …
PARP in the neuropathogenesis of cytomegalovirus infection–Possible role and therapeutic perspective
Cytomegalovirus infects the majority of the population globally. Congenital CMV infection
acquired through primary maternal infection in pregnancy is the most common intrauterine …
acquired through primary maternal infection in pregnancy is the most common intrauterine …
The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.
W Yongkun, LI Yingchun, RAN Cui, LE Wenjun… - …, 2023 - search.ebscohost.com
Pancreatic cancer is one of the most lethal tumors due to its rapid proliferation and
aggressiveness. RAD51AP1 is a protein-coding gene with critical functions in many cancers …
aggressiveness. RAD51AP1 is a protein-coding gene with critical functions in many cancers …
[HTML][HTML] 聚ADP 核糖聚合酶-1 与原发性肝癌的研究进展
阙克婷， 刘作金， 李钺 - Advances in Clinical Medicine, 2022 - hanspub.org
最新统计数据表明, 原发性肝癌(hepatocellular carcinoma, HCC) 是世界上第二大致病率肿瘤,
它有很高的复发率及很低的5 年生存率, 且它的治疗选择有限. 然而每年的新发例数却在逐年 …
它有很高的复发率及很低的5 年生存率, 且它的治疗选择有限. 然而每年的新发例数却在逐年 …
[HTML][HTML] ПАРТАНАТОЗ И ОНКОГЕНЕЗ ПЕЧЕНИ
ВМ Цыркунов, СШ Керимова… - Гепатология и …, 2023 - cyberleninka.ru
В обзоре представлена информация о редком виде программируемой
неапоптотической гибели клеток–партанатозе, механизмах его развития, активации и …
неапоптотической гибели клеток–партанатозе, механизмах его развития, активации и …