Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G Xiao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Niclosamide: Beyond an antihelminthic drug

W Chen, RA Mook Jr, RT Premont, J Wang - Cellular signalling, 2018 - Elsevier
Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of
people worldwide. However recent studies have indicated that niclosamide may have broad …

New trends in platinum and palladium complexes as antineoplastic agents

M Fanelli, M Formica, V Fusi, L Giorgi… - Coordination Chemistry …, 2016 - Elsevier
The discovery of cisplatin (cis-Pt (NH 3) 2 Cl 2) as an antineoplastic agent has focussed
attention on the rational design of metal complexes that can be potentially used in cancer …

New drugs are not enough-drug repositioning in oncology: An update

RG Armando, DLM Gomez… - … Journal of Oncology, 2020 - spandidos-publications.com
Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Metal complexes against breast cancer stem cells

Y Li, B Liu, H Shi, Y Wang, Q Sun, Q Zhang - Dalton Transactions, 2021 - pubs.rsc.org
With the highest incidence, breast cancer is the leading cause of cancer deaths among
women in the world. Tumor metastasis is the major contributor of high mortality in breast …

Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy

S Alcalá, L Villarino, L Ruiz-Cañas, JR Couceiro… - Journal of Experimental …, 2024 - Springer
Background Previous studies by our group have shown that oxidative phosphorylation
(OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their …

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete …

B Cevatemre, M Erkısa, N Aztopal, D Karakas… - Pharmacological …, 2018 - Elsevier
Several natural products have been suggested as effective agents for the treatment of
cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy …

[HTML][HTML] Metal complexes of saccharin and thiosaccharin as potential anticancer and antimicrobial agents

C Icsel, VT Yilmaz, OZ Yesilel, WTA Harrison - European Journal of …, 2024 - Elsevier
Based on the chemotherapeutic success of cisplatin, carboplatin and oxaliplatin as
anticancer drugs, and silver sulfadiazine (AgSDZ) as an antibacterial drug, exploration of the …

Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells

N Aztopal, M Erkisa, E Erturk, E Ulukaya… - Chemico-Biological …, 2018 - Elsevier
Cancer stem–like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist
chemotherapy, give rise to metastases and lead to disease relapse because of an acquired …

The Next Generation of Anticancer Metallopharmaceuticals: Cancer Stem Cell‐Active Inorganics

K Laws, K Suntharalingam - ChemBioChem, 2018 - Wiley Online Library
Cancer stem cells (CSCs) are heavily linked to fatal incidences of cancer relapse and
metastasis. Conventional cancer therapies such as surgery, chemotherapy and radiation are …