Mitochondria are among the most important cell organelles involved in the regulation of
intracellular calcium homeostasis. During the last decade, a number of molecular structures …

The expansion of computational power, better parameterization of force fields, and the
development of novel algorithms to enhance the sampling of the free energy landscapes of …

Abstract Na+/Ca2+ exchangers (NCX) transport Ca2+ in or out of cells in exchange for Na+.
They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca2+ …

Sodium-calcium exchanger proteins influence calcium homeostasis in many cell types and
participate in a wide range of physiological and pathological processes. Here, we elucidate …

Neurodegenerative diseases (NDDs) are a range of neurological disorders featured by
neuronal degeneration and apoptosis. Cellular Calcium (Ca 2+) and reactive oxygen …

The fabrication of a membrane with the capability of chiral selective transport is a big
challenge in the membrane separation of chiral drugs. To solve the problem of chiral …

Background Salinity, as one of the main abiotic stresses, critically threatens growth and
fertility of main food crops including rice in the world. To get insight into the molecular …

Ca 2+ homeostasis is essential for cell function and survival. As such, the cytosolic Ca 2+
concentration is tightly controlled by a wide number of specialized Ca 2+ handling proteins …

Calmodulin (CaM) is a calcium sensing protein that regulates the function of a large number
of proteins, thus playing a crucial part in many cell signaling pathways. CaM has the ability …

The transmembrane sodium-calcium (Na-Ca) exchanger 1 (NCX1) regulates cytoplasmic
Ca levels by facilitating electrogenic exchange of Ca for Na. Palmitoylation, the only …