Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Horizontal transfer of antibiotic resistance genes in clinical environments

NA Lerminiaux, ADS Cameron - Canadian journal of …, 2019 - cdnsciencepub.com
A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …

Antimicrobial resistance: more than 70 years of war between humans and bacteria

SF Nadeem, UF Gohar, SF Tahir… - Critical Reviews in …, 2020 - Taylor & Francis
Abstract Development of antibiotic resistance in bacteria is one of the major issues in the
present world and one of the greatest threats faced by mankind. Resistance is spread …

Bacteriophage and bacterial susceptibility, resistance, and tolerance to antibiotics

Q Chen, T Dharmaraj, PC Cai, EB Burgener… - Pharmaceutics, 2022 - mdpi.com
Bacteriophages, viruses that infect and replicate within bacteria, impact bacterial responses
to antibiotics in complex ways. Recent studies using lytic bacteriophages to treat bacterial …

Phage therapy: what have we learned?

A Górski, R Międzybrodzki, M Łobocka… - Viruses, 2018 - mdpi.com
In this article we explain how current events in the field of phage therapy may positively
influence its future development. We discuss the shift in position of the authorities …

Multi-species host range of staphylococcal phages isolated from wastewater

PC Göller, T Elsener, D Lorgé, N Radulovic… - Nature …, 2021 - nature.com
The host range of bacteriophages defines their impact on bacterial communities and
genome diversity. Here, we characterize 94 novel staphylococcal phages from wastewater …

Methicillin Resistant Staphylococcus aureus: Molecular Mechanisms Underlying Drug Resistance Development and Novel Strategies to Combat

AA Abebe, AG Birhanu - Infection and Drug Resistance, 2023 - Taylor & Francis
Antimicrobial resistance (AMR) represents a major threat to global health. Infection caused
by Methicillin-resistant Staphylococcus aureus (MRSA) is one of the well-recognized global …

Current updates from the long-standing phage research centers in Georgia, Poland, and Russia

R Międzybrodzki, N Hoyle, F Zhvaniya… - Bacteriophages: biology …, 2021 - Springer
Abstract The George Eliava Institute of Bacteriophages, Microbiology and Virology (IBMV) in
Tbilisi, Georgia; the Hirszfeld Institute of Immunology and Experimental Therapy in Wroclaw …

Temperate Phages of Staphylococcus aureus

H Ingmer, D Gerlach, C Wolz - Microbiology spectrum, 2019 - Am Soc Microbiol
Most Staphylococcus aureus isolates carry multiple bacteriophages in their genome, which
provide the pathogen with traits important for niche adaptation. Such temperate S. aureus …

Exploring the profile of antimicrobial resistance genes harboring by bacteriophage in chicken feces

Y Yang, X Xie, M Tang, J Liu, H Tuo, J Gu… - Science of the Total …, 2020 - Elsevier
Bacteriophage may play an important role in antimicrobial resistance genes (ARGs)
transmission. However, the contribution of bacteriophage to the spread of ARGs in …