Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …

Artemisinins–the frontline antimalarial drug class–are compromised by emerging resistance,
putting at risk the lives of hundreds of thousands of people each year. Resistance is …

Emergence and spread of resistance in Plasmodium falciparum to the frontline treatment
artemisinin-based combination therapies (ACTs) in the epicenter of multidrug resistance of …

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials
creates an imperative to identify and develop potent preclinical candidates with distinct …

The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic
parasites has led to increasing treatment failure rates with first-line ART-based combination …

Endocytosis is critical for many functions in eukaryotic cells. Uptake of host cell cytosol, an
indispensable endocytic process in malaria blood-stage parasites, has been known for a …

Apicomplexan parasites have immense impacts on humanity, but their basic cellular
processes are often poorly understood. Where endocytosis occurs in these cells, how …

Despite a significant decline in morbidity and mortality over the last two decades, in 2018
there were 228 million reported cases of malaria and 405000 malaria-related deaths …

Molecular surveillance for malaria has great potential to support national malaria control
programs (NMCPs). To bridge the gap between research and implementation, several …

Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced
susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work …