Utilization of kinase inhibitors as novel therapeutic drug targets: A review

S Nishal, V Jhawat, S Gupta, P Phaugat - Oncology research, 2023 - pmc.ncbi.nlm.nih.gov
Kinase inhibitors are a significant and continuously developing division of target
therapeutics. The drug discovery and improvement efforts have examined numerous …

Diversity‐Oriented Catalytic Asymmetric Dearomatization of Indoles with o‐Quinone Diimides

HJ Gao, YH Miao, WN Sun, R Zhao, X Xiao… - Advanced …, 2023 - Wiley Online Library
Herein, the first diversity‐oriented catalytic asymmetric dearomatization of indoles with o‐
quinone diimides (o‐QDIs) is reported. The catalytic asymmetric dearomatization (CADA) of …

Halogen Regulation in Vinylene-Linked Covalent Organic Frameworks for Efficient Photocatalytic C–H Thiolation of Quinone Derivatives

K Zhao, H Qiao, S Wang, X Xu, C Wang… - ACS Materials …, 2023 - ACS Publications
Vinylene-linked covalent organic frameworks (COFs) are considered promising
heterogeneous photocatalyst candidates for organic synthesis because of their robust and …

[HTML][HTML] Unraveling the Aurora kinase A and Epstein-Barr nuclear antigen 1 axis in Epstein Barr virus associated gastric cancer

N Varshney, S Murmu, B Baral, D Kashyap, S Singh… - Virology, 2023 - Elsevier
Aurora kinase A (AURKA) is one of the crucial cell cycle regulators associated with gastric
cancer. Here, we explored Epstein Barr Virus-induced gastric cancer progression through …

Recent advancements in mechanistic Research, therapeutic Potential, and Structure-Activity relationships of Aurora kinase inhibitors in cancer therapies

G Teli, L Maji, R Pal, N Maheshwari, GSP Matada… - Bioorganic …, 2024 - Elsevier
Aurora kinases (AURKs)—a family of serine/threonine protein kinases consisting of AURK-
A, AURK-B, and AURK-C, are critical regulators of chromosomal segregation, centrosome …

Probing Baicalin as potential inhibitor of Aurora kinase B: a step towards lung cancer therapy

S Noor, A Choudhury, A Raza, A Ashraf… - International Journal of …, 2024 - Elsevier
Cell cycle regulators play pivotal roles as their dysregulation, leads to atypical proliferation
and intrinsic genomic instability in cancer cells. Abnormal expression and functioning of …

Design, synthesis, and biological evaluation of SSE1806, a microtubule destabilizer that overcomes multidrug resistance

F Firdous, S Riaz, M Furqan, S Fozail… - ACS Medicinal …, 2023 - ACS Publications
Microtubules are dynamic structures that form spindle fibers during cell division;
pharmacological inhibition of microtubule dynamics arrests cells in mitosis, leading to …

Synthesis and characterization of bis-amide SSE1917 as a microtubule-stabilizing anticancer agent

S Iqbal, F Firdous, M Furqan, A Bilal, S Fozail… - Bioorganic …, 2024 - Elsevier
Microtubule dynamics are critical for spindle assembly and chromosome segregation during
cell division. Pharmacological inhibition of microtubule dynamics in cells causes prolonged …

Biological activity of naphthoquinones derivatives in the search of anticancer lead compounds

AG Durán, N Chinchilla, AM Simonet, MT Gutiérrez… - Toxins, 2023 - mdpi.com
Naphthoquinones are a valuable source of secondary metabolites that are well known for
their dye properties since ancient times. A wide range of biological activities have been …

Catalytic Asymmetric Dearomative Arylation of 2‐Naphthols Enabled by o‐Quinone Diimides

YY Li, FY Yang, MY Wu, L Huang… - Advanced Synthesis & …, 2024 - Wiley Online Library
The catalytic asymmetric dearomative arylation of 2‐naphthols enabled by the
unconventional reactivity of o‐quinone diimides, ie the 1, 4‐conjugate addition on quinone …