Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …

Scientific and clinical progress together with the development of effective novel therapeutic
options has engendered multiple important changes in the diagnosis and management of …

This is an update to the 2014 Canadian Hereditary Angioedema Guideline with an
expanded scope to include the management of hereditary angioedema (HAE) patients …

Background Hereditary angioedema (HAE) is a potentially fatal disorder resulting in
recurrent attacks of severe swelling. It may be associated with a genetic deficiency of …

Hereditary Angioedema Hereditary angioedema is a rare genetic disease that may include
recurrent attacks of cutaneous angioedema, severe abdominal pain, and airway …

Background Hereditary angioedema (HAE) with normal C1 inhibitor (C1-INH)(HAEnCI) is
associated with skin swellings, abdominal attacks, and the risk of asphyxia due to upper …

Background Hereditary angioedema (HAE) is a rare disease characterized by
unpredictable, potentially life-threatening attacks, resulting in significant physical and …

Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is
associated with point mutations in the gene encoding the plasma protease factor XII (FXII) …

Complement deficiencies comprise between 1 and 10% of all primary immunodeficiencies
(PIDs) according to national and supranational registries. They are still considered rare and …

Contemporary genetic research has provided evidences that angioedema represents a
diverse family of disorders related to kinin metabolism, with a much greater genetic …