Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases

SC Funes, M Rios, A Fernández-Fierro… - Frontiers in …, 2020 - frontiersin.org
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group
degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which …

Oxidative stress-mediated HMGB1 biology

Y Yu, D Tang, R Kang - Frontiers in physiology, 2015 - frontiersin.org
High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundant protein that
acts as an extracellular signal upon active secretion by immune cells or passive release by …

[HTML][HTML] Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers

Y Guo, B Balasubramanian, ZH Zhao, WC Liu - Poultry science, 2021 - Elsevier
Abstract Aflatoxin B1 (AFB1) causes toxic effect and leads to organ damage in broilers.
Marine algal polysaccharides (MAP) of Enteromorpha prolifera exert multiple biological …

Quercetin attenuates inflammatory responses in BV-2 microglial cells: role of MAPKs on the Nrf2 pathway and induction of heme oxygenase-1

GY Sun, Z Chen, KJ Jasmer, DY Chuang, Z Gu… - PloS one, 2015 - journals.plos.org
A large group of flavonoids found in fruits and vegetables have been suggested to elicit
health benefits due mainly to their anti-oxidative and anti-inflammatory properties. Recent …

[HTML][HTML] Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and …

C Li, WJ Zhang, B Frei - Redox biology, 2016 - Elsevier
Atherosclerosis, the underlying cause of ischemic heart disease and stroke, is an
inflammatory disease of arteries in a hyperlipidemic milieu. Endothelial expression of …

Anti-Inflammatory Effects of Neochlorogenic Acid Extract from Mulberry Leaf (Morus alba L.) Against LPS-Stimulated Inflammatory Response through Mediating the …

X Gao, S Zhang, L Wang, L Yu, X Zhao, H Ni, Y Wang… - Molecules, 2020 - mdpi.com
Neochlorogenic acid (nCGA) is a phenolic compound isolated from mulberry leaf (Morus
alba L.), which possesses multiple pharmacological activities containing antioxidant and anti …

Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-κB pathway

CM Liu, JQ Ma, WR Xie, SS Liu, ZJ Feng… - Food and Chemical …, 2015 - Elsevier
Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal
properties. However, its protective effects against nickel (Ni) induced injury in liver have not …

[HTML][HTML] ATF3-mediated NRF2/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia/reperfusion injury

J Rao, X Qian, G Li, X Pan, C Zhang, F Zhang… - American Journal of …, 2015 - Elsevier
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that has been
shown to repress inflammatory gene expression in multiple cell types and diseases …

Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways

C Sturm, AE Wagner - International Journal of Molecular Sciences, 2017 - mdpi.com
A high consumption of vegetables belonging to the Brassicaceae family has been related to
a lower incidence of chronic diseases including different kinds of cancer. These beneficial …

Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway

Y Zhang, KA Ahmad, FU Khan, S Yan, AU Ihsan… - Chemico-Biological …, 2019 - Elsevier
Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs; however, the
incidence of cardiotoxicity compromises its therapeutic index. Oxidative stress and apoptosis …