Cancer can be perceived as a disease of communication between and within cells. The
aberrations are pleiotropic, but mitogen-activated protein kinase (MAPK) pathways feature …

RAF-kinase inhibitor protein (RKIP) is a well-established tumor suppressor that is frequently
downregulated in a plethora of solid and hematological malignancies. RKIP exerts …

Epithelial-mesenchymal transition (EMT) is a key event in the generation of invasive tumor
cells. A hallmark of EMT is the repression of E-cadherin expression, which is regulated by …

Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear
factor κB signaling that represses tumor invasion and metastasis. Glycogen synthase kinase …

From its discovery as a phosphatidylethanolamine‐binding protein in bovine brain to its
designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical …

Background: Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine
binding protein (PEBP) family that is expressed in both prokaryotic and euakaryotic …

Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a
metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a …

The majority of cancers develop genetic and molecular strategies to resist conventional
cytotoxic therapies as well as escape from the host's immune surveillance. These events …

In developed countries, colorectal cancer (CRC) is the third most common malignancy, but it
is the second most frequent cause of cancer-related death. Clinicians are still faced with …

Raf kinase inhibitor protein (RKIP), an inhibitor of several signaling pathways, has been
shown to have metastasis suppressor gene activity and promote apoptosis. While first …