Tumor initiation and progression are somatic evolutionary processes driven by the
accumulation of genetic alterations, some of which confer selective fitness advantages to the …

Evolutionary game theory mathematically conceptualizes and analyzes biological
interactions where one's fitness not only depends on one's own traits, but also on the traits of …

Under the background of the aging population and the improvement of people's quality of
life, the demand for household medical devices is expanding, which has huge market …

Purpose: Integration of evolutionary dynamics into systemic therapy for metastatic cancers
can prolong tumor control compared with standard maximum tolerated dose (MTD) …

In the absence of curative therapies, treatment of metastatic castrate-resistant prostate
cancer (mCRPC) using currently available drugs can be improved by integrating …

Computational models can be applied to optimize treatment schedules and model treatment
responses in cancer therapy. In this Review, we provide an overview of such computational …

In this study, we experimentally measure the frequency-dependent interactions between a
gefitinib-resistant non–small cell lung cancer population and its sensitive ancestor via the …

We present a game-theoretic model of a polymorphic cancer cell population where the
treatment-induced resistance is a quantitative evolving trait. When stabilization of the tumor …

In this review, we consider the role of cell-cell fusion in cancer development and progression
through an evolutionary lens. We begin by summarizing the origins of fusion proteins …

While acquired chemoresistance is recognized as a key challenge to treating many types of
cancer, the dynamics with which drug sensitivity changes after exposure are poorly …