Integrator is a global promoter-proximal termination complex
Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
SA Welsh, A Gardini - Nature Reviews Molecular Cell Biology, 2023 - nature.com
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release
Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …
and has been proposed to regulate transcription initiation,. However, redundant functions of …
Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci
Summary RNA polymerase II (RNAPII) pausing in early elongation is critical for gene
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …
Structural basis of Integrator-mediated transcription regulation
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates
paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription …
paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription …
Born to run: control of transcription elongation by RNA polymerase II
FX Chen, ER Smith, A Shilatifard - Nature reviews Molecular cell …, 2018 - nature.com
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
[HTML][HTML] The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
SJ Vervoort, SA Welsh, JR Devlin, E Barbieri… - Cell, 2021 - cell.com
Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …
Getting up to speed with transcription elongation by RNA polymerase II
Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
INTRODUCTION RNA cleavage and phosphorylation-dephosphorylation of the RNA
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …
Diversity and emerging roles of enhancer RNA in regulation of gene expression and cell fate
PR Arnold, AD Wells, XC Li - Frontiers in cell and developmental …, 2020 - frontiersin.org
Enhancers are cis-regulatory elements in the genome that cooperate with promoters to
control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent …
control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent …