Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID …

Several biologic therapies have been developed to treat moderate-to-severe psoriasis, with
patients exhibiting different clinical benefits, possibly due to the heterogeneity of pathogenic …

Background Palmoplantar pustulosis (PPP) is an inflammatory skin disorder that mostly
affects smokers and manifests with painful pustular eruptions on the palms and soles …

SARS-CoV-2 enters host cells by binding angiotensin-converting enzyme 2 (ACE2).
Through a genome-wide association study, we show that a rare variant (MAF= 0.3%, odds …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
coronavirus disease 2019 (COVID-19) global public health emergency, and the disease it …

ABSTRACT G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell
surface signaling proteins that share a common structural topology. When compared with …

The need to identify and effectively treat COVID-19 cases at highest risk for severe disease
is critical. We identified seven common genetic variants (three novel) that modulate COVID …

Glucocorticoids have multiple therapeutic benefits and are used both for
immunosuppression and treatment purposes. Notwithstanding their benefits, glucocorticoid …

Introduction Immunotherapy with biologics targeting programmed cell death protein-1 (PD-1)
is highly effective in the treatment of various malignancies. Nevertheless, it is frequently …

Background The centrosome is one of the most important non-membranous organelles
regulating microtubule organization and progression of cell mitosis. The coiled-coil alpha …