The complement system in age-related macular degeneration

A Armento, M Ueffing, SJ Clark - Cellular and Molecular Life Sciences, 2021 - Springer
Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

Oxidative stress and antioxidants in age-related macular degeneration

N Kushwah, K Bora, M Maurya, MC Pavlovich, J Chen - Antioxidants, 2023 - mdpi.com
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Age-related macular degeneration

EK de Jong, MJ Geerlings, AI den Hollander - Genetics and genomics of …, 2020 - Elsevier
Age-related macular degeneration (AMD) is a multifactorial disease influenced by a
combination of environmental factors and genetic variants. Genomic studies have been …

Retinal microglia–A key player in healthy and diseased retina

G Rathnasamy, WS Foulds, EA Ling, C Kaur - Progress in neurobiology, 2019 - Elsevier
Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …

Progression of geographic atrophy in age-related macular degeneration: AREDS2 report number 16

TD Keenan, E Agrón, A Domalpally, TE Clemons… - Ophthalmology, 2018 - Elsevier
Purpose To analyze the prevalence, incidence, and clinical characteristics of eyes with
geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and …

[HTML][HTML] Aging of the eye: Lessons from cataracts and age-related macular degeneration

A Cvekl, J Vijg - Ageing Research Reviews, 2024 - Elsevier
Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …

On phagocytes and macular degeneration

X Guillonneau, CM Eandi, M Paques, JA Sahel… - Progress in retinal and …, 2017 - Elsevier
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …

[HTML][HTML] Genetic risk, lifestyle, and age-related macular degeneration in Europe: the EYE-RISK Consortium

JM Colijn, M Meester-Smoor, T Verzijden, A de Breuk… - Ophthalmology, 2021 - Elsevier
Purpose Age-related macular degeneration (AMD) is a common multifactorial disease in the
elderly with a prominent genetic basis. Many risk variants have been identified, but the …

The 10q26 risk haplotype of age-related macular degeneration aggravates subretinal inflammation by impairing monocyte elimination

F Beguier, M Housset, C Roubeix, S Augustin, Y Zagar… - Immunity, 2020 - cell.com
A minor haplotype of the 10q26 locus conveys the strongest genetic risk for age-related
macular degeneration (AMD). Here, we examined the mechanisms underlying this …

Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration

Y Pan, Y Fu, PN Baird, RH Guymer, T Das… - Progress in Retinal and …, 2023 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …