In Vitro Bone Cell Models: Impact of Fluid Shear Stress on Bone Formation

C Wittkowske, GC Reilly, D Lacroix… - … in bioengineering and …, 2016 - frontiersin.org
This review describes the role of bone cells and their surrounding matrix in maintaining
bone strength through the process of bone remodeling. Subsequently, this work focusses on …

3D traction force microscopy in biological gels: from single cells to multicellular spheroids

BCH Cheung, RJ Abbed, M Wu… - Annual Review of …, 2024 - annualreviews.org
Cell traction force plays a critical role in directing cellular functions, such as proliferation,
migration, and differentiation. Current understanding of cell traction force is largely derived …

[HTML][HTML] From bone regeneration to three-dimensional in vitro models: tissue engineering of organized bone extracellular matrix

BWM de Wildt, S Ansari, NAJM Sommerdijk… - Current opinion in …, 2019 - Elsevier
Traditionally, bone tissue engineering has been used for creating implants for bone
regeneration, but recently, it is increasingly applied to create three-dimensional (3D) in vitro …

Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds

BM Nitschke, FO Beltran, MS Hahn… - Journal of Materials …, 2024 - pubs.rsc.org
Due to limitations of biological and alloplastic grafts, regenerative engineering has emerged
as a promising alternative to treat bone defects. Bioactive polymeric scaffolds are an integral …

Identification of stiffness-induced signalling mechanisms in cells from patent and fused sutures associated with craniosynostosis

S Barreto, A González-Vázquez, A R. Cameron… - Scientific reports, 2017 - nature.com
Craniosynostosis is a bone developmental disease where premature ossification of the
cranial sutures occurs leading to fused sutures. While biomechanical forces have been …

Adsorption force of fibronectin controls transmission of cell traction force and subsequent stem cell fate

M Lin, S Mao, J Wang, J Xing, Y Wang, K Cai, Y Luo - Biomaterials, 2018 - Elsevier
The transmission of cell traction force (CTF) to underlying biomaterials is essential for
adhered cells to measure and respond to their mechanical microenvironment. Given that the …

In vitro bioprinted 3D model enhancing osteoblast-to-osteocyte differentiation

S Pragnere, L Essayan, N El-Kholti, E Petiot… - …, 2024 - iopscience.iop.org
In vitro bone models are pivotal for understanding tissue behavior and cellular responses,
particularly in unravelling certain pathologies' mechanisms and assessing the impact of new …

Long-term and label-free monitoring for osteogenic differentiation of mesenchymal stem cells using force sensor and impedance measurement

Z Zhang, T Zheng, R Zhu - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Stem cells have attracted increasing research interest in the field of regenerative medicine
due to their unique abilities to differentiate into multiple cell lineages. Label-free, real-time …

On the biomechanical properties of osteosarcoma cells and their environment

DA Müller, U Silvan - The International journal of developmental biology, 2019 - zora.uzh.ch
Although rare among the general population, bone malignancies have a high rate of
incidence among children and adolescents and are associated with high mortality rates …

Instantaneous 4D micro-particle image velocimetry (µPIV) via multifocal microscopy (MUM)

MGR Guastamacchia, R Xue, K Madi… - Scientific Reports, 2022 - nature.com
Multifocal microscopy (MUM), a technique to capture multiple fields of view (FOVs) from
distinct axial planes simultaneously and on one camera, was used to perform micro-particle …