The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that
affect people of all ages and ethnicities but are most prevalent in children. Commonly known …

The neonatal mouse heart is capable of transiently regenerating after injury from postnatal
day (P) 0-7 and macrophages are found important in this process. However, whether …

Stroke is a life-threatening medical condition and is a leading cause of disability. Cerebral
ischemia is characterized by a distinct inflammatory response starting with the production of …

There is a well-established link between cytokine expression and the progression of
intervertebral disc degeneration. Among these cytokines, interleukin-1β (IL-1β) and tumor …

Promotion of corneal dense network of nerve is a promising method to treat severe corneal
injury, yet with limited effective drugs. In our previous work, decellularized matrix of adipose …

Motor neuron (MN) development and nerve regeneration requires orchestrated action of a
vast number of molecules. Here, we identify SorCS2 as a progranulin (PGRN) receptor that …

Progranulin (PGRN), a secreted glycosylated protein, has been reported to attenuate
ischemia-induced cerebral injury through anti-inflammation, attenuation of blood-brain …

Progranulin (PGRN) is a secreted glycoprotein with multiple biological functions in early
embryogenesis, anti‐inflammation, and neurodegeneration. A good model for the functional …

Objective The growth factor progranulin (PGRN) is widely expressed and plays important
roles in anti-inflammatory signaling and bone regeneration. However, the anti-inflammatory …

Astrocytes are glial cells that support and protect neurons in the central nervous systems
including the retina. Retinal ganglion cells (RGCs) are in contact with the astrocytes and our …