Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and
memory. While the mechanisms underlying the induction of LTP ('learning') are well …

Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

Considerable genetic variation of N-methyl-d-aspartate receptors (NMDARs) has recently
become apparent, with many hundreds of de novo variants identified through widely …

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory neurotransmission in the central nervous system. iGluRs open their ion …

Animal ionotropic glutamate receptors (iGluRs) are ligand-gated channels whose evolution
is intimately linked to that of the nervous system, where the agonist glutamate and co …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that contribute to nearly all
brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR …

Kinetics of NMDA receptor (NMDAR) ion channel opening and closing contribute to their
unique role in synaptic signaling. Agonist binding generates free energy to open a canonical …

A variety of de novo and inherited missense mutations associated with neurological
disorders are found in the NMDA receptor M4 transmembrane helices, which are peripheral …