Organotypic vasculature: from descriptive heterogeneity to functional pathophysiology
HG Augustin, GY Koh - Science, 2017 - science.org
BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …
distinctive and versatile functions in response to dynamically changing systemic and local …
The deployment of cell lineages that form the mammalian heart
SM Meilhac, ME Buckingham - Nature Reviews Cardiology, 2018 - nature.com
The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …
types. The deployment of these cells, with precise spatiotemporal regulation, is also …
Notch and interacting signalling pathways in cardiac development, disease, and regeneration
D MacGrogan, J Münch, JL de la Pompa - Nature Reviews Cardiology, 2018 - nature.com
Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …
The senescence markers p16INK4A, p14ARF/p19ARF, and p21 in organ development and homeostasis
KD Wagner, N Wagner - Cells, 2022 - mdpi.com
It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …
replicative arrest and the release of a myriad of factors commonly called the senescence …
The role of the epicardium during heart development and repair
The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …
important cellular contributions for embryonic heart formation. The epicardium harbors a …
Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases
Endothelial cells and mesenchymal cells are two different cell types with distinct
morphologies, phenotypes, functions, and gene profiles. Accumulating evidence, notably …
morphologies, phenotypes, functions, and gene profiles. Accumulating evidence, notably …
Wilms' tumour 1 (WT1) in development, homeostasis and disease
ND Hastie - Development, 2017 - journals.biologists.com
The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …
Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid
The epicardium, the outer epithelial layer that covers the myocardium, derives from a
transient organ known as pro-epicardium, crucial during heart organogenesis. The pro …
transient organ known as pro-epicardium, crucial during heart organogenesis. The pro …
Role of resident stem cells in vessel formation and arteriosclerosis
L Zhang, S Issa Bhaloo, T Chen, B Zhou… - Circulation research, 2018 - Am Heart Assoc
Vascular, resident stem cells are present in all 3 layers of the vessel wall; they play a role in
vascular formation under physiological conditions and in remodeling in pathological …
vascular formation under physiological conditions and in remodeling in pathological …