Organotypic vasculature: from descriptive heterogeneity to functional pathophysiology

HG Augustin, GY Koh - Science, 2017 - science.org
BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …

EMT: 2016

MA Nieto, RYJ Huang, RA Jackson, JP Thiery - cell, 2016 - cell.com
The significant parallels between cell plasticity during embryonic development and
carcinoma progression have helped us understand the importance of the epithelial …

The deployment of cell lineages that form the mammalian heart

SM Meilhac, ME Buckingham - Nature Reviews Cardiology, 2018 - nature.com
The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

Notch and interacting signalling pathways in cardiac development, disease, and regeneration

D MacGrogan, J Münch, JL de la Pompa - Nature Reviews Cardiology, 2018 - nature.com
Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

The senescence markers p16INK4A, p14ARF/p19ARF, and p21 in organ development and homeostasis

KD Wagner, N Wagner - Cells, 2022 - mdpi.com
It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

The role of the epicardium during heart development and repair

P Quijada, MA Trembley, EM Small - Circulation research, 2020 - Am Heart Assoc
The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases

Y Li, KO Lui, B Zhou - Nature Reviews Cardiology, 2018 - nature.com
Endothelial cells and mesenchymal cells are two different cell types with distinct
morphologies, phenotypes, functions, and gene profiles. Accumulating evidence, notably …

Wilms' tumour 1 (WT1) in development, homeostasis and disease

ND Hastie - Development, 2017 - journals.biologists.com
The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid

MA Branco, TP Dias, JMS Cabral, P Pinto-do-Ó… - Nature …, 2022 - nature.com
The epicardium, the outer epithelial layer that covers the myocardium, derives from a
transient organ known as pro-epicardium, crucial during heart organogenesis. The pro …

Role of resident stem cells in vessel formation and arteriosclerosis

L Zhang, S Issa Bhaloo, T Chen, B Zhou… - Circulation research, 2018 - Am Heart Assoc
Vascular, resident stem cells are present in all 3 layers of the vessel wall; they play a role in
vascular formation under physiological conditions and in remodeling in pathological …