Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …

Toxicity prediction is very important to public health. Among its many applications, toxicity
prediction is essential to reduce the cost and labor of a drug's preclinical and clinical trials …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …

Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 …

We present Vision, a tool for annotating the sources of variation in single cell RNA-seq data
in an automated and scalable manner. Vision operates directly on the manifold of cell-cell …

Human gene networks have proven useful in many aspects of disease research, with
numerous network-based strategies developed for generating hypotheses about gene …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), better known as
COVID-19, has become a current threat to humanity. The second wave of the SARS-CoV-2 …

SARS-CoV-2 has ushered a global pandemic with no effective drug being available at
present. Although several FDA-approved drugs are currently under clinical trials for drug …

Abstract Motivation Gene Set Enrichment Analysis (GSEA) is routinely used to analyze and
interpret coordinate pathway-level changes in transcriptomics experiments. For an …

Circadian rhythms modulate many aspects of physiology. Knowledge of the molecular basis
of these rhythms has exploded in the last 20 years. However, most of these data are from …