Current status and future prospects of marine natural products (MNPs) as antimicrobials
A Choudhary, LM Naughton, I Montánchez… - Marine drugs, 2017 - mdpi.com
The marine environment is a rich source of chemically diverse, biologically active natural
products, and serves as an invaluable resource in the ongoing search for novel …
products, and serves as an invaluable resource in the ongoing search for novel …
Muscarine, imidazole, oxazole and thiazole alkaloids
Z Jin - Natural product reports, 2016 - pubs.rsc.org
Covering: July 2012 to June 2015. Previous review: Nat. Prod. Rep., 2013, 30, 869–915 The
structurally diverse imidazole-, oxazole-, and thiazole-containing secondary metabolites are …
structurally diverse imidazole-, oxazole-, and thiazole-containing secondary metabolites are …
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site
T Tomasic, S Katsamakas, Z Hodnik… - Journal of medicinal …, 2015 - ACS Publications
Bacterial DNA gyrase and topoisomerase IV are essential enzymes that control the
topological state of DNA during replication and validated antibacterial drug targets. Starting …
topological state of DNA during replication and validated antibacterial drug targets. Starting …
An updated review on the synthesis and antibacterial activity of molecular hybrids and conjugates bearing imidazole moiety
R Rossi, M Ciofalo - Molecules, 2020 - mdpi.com
The rapid growth of serious infections caused by antibiotic resistant bacteria, especially the
nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists …
nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists …
Natural indole‐containing alkaloids and their antibacterial activities
Y Liu, Y Cui, L Lu, Y Gong, W Han… - Archiv der …, 2020 - Wiley Online Library
As the growth in resistance to bacterial infection treatments poses a grave threat to global
health in the 21st century, there is a constant need to explore novel antibacterial agents that …
health in the 21st century, there is a constant need to explore novel antibacterial agents that …
A metal-organic frameworks@ carbon nanotubes based electrochemical sensor for highly sensitive and selective determination of ascorbic acid
Y Li, W Ye, Y Cui, B Li, Y Yang, G Qian - Journal of Molecular Structure, 2020 - Elsevier
A conductive electrochemical sensor for ascorbic acid was prepared by in-situ growing
metal-organic frameworks (ZIF-65) on the surface of carboxylated carbon nanotubes. This …
metal-organic frameworks (ZIF-65) on the surface of carboxylated carbon nanotubes. This …
Novel combretastatin-2-aminoimidazole analogues as potent tubulin assembly inhibitors: exploration of unique pharmacophoric impact of bridging skeleton and aryl …
V Chaudhary, JB Venghateri… - Journal of medicinal …, 2016 - ACS Publications
Combretastatin A-4 (CA-4) in phosphate and serine pro-drug forms is under phase II clinical
trials. With our interest of discovering CA-4 inspired new chemical entities, a novel series of …
trials. With our interest of discovering CA-4 inspired new chemical entities, a novel series of …
Exploring the chemical space of benzothiazole-based DNA gyrase B inhibitors
Z Skok, M Barančoková, O Benek… - ACS medicinal …, 2020 - ACS Publications
We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase
and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor …
and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor …
Recent progress in the discovery and development of DNA gyrase B inhibitors
New antibacterials that modulate less explored targets are needed to fight the emerging
bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search …
bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search …
N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation
Bacterial DNA gyrase is a well-known and validated target in the design of antibacterial
drugs. However, inhibitors of its ATP binding subunit, DNA gyrase B (GyrB), have so far not …
drugs. However, inhibitors of its ATP binding subunit, DNA gyrase B (GyrB), have so far not …