Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Elucidating enzyme–substrate relationships in posttranslational modification (PTM) networks
is crucial for understanding signal transduction pathways but is technically difficult because …

Multicellular organisms depend on physical cell–cell interactions to control physiological
processes such as tissue formation, neurotransmission and immune response. These …

Proximity-dependent biotinylation (PDB) combined with mass spectrometry analysis has
established itself as a key technology to study protein-protein interactions in living cells. A …

Proximity labeling (PL) with genetically-targeted promiscuous enzymes has emerged as a
powerful tool for unbiased proteome discovery. By combining the spatiotemporal specificity …

Proteins are workhorses in the cell; they form stable and more often dynamic, transient
protein–protein interactions, assemblies, and networks and have an intimate interplay with …

Characterizing the proteome composition of organelles and subcellular regions of living
cells can facilitate the understanding of cellular organization as well as protein interactome …

Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for
mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose …

To explore changes in proteins and metabolites under stress circumstances, genomics,
proteomics, and metabolomics methods are used. In-depth research over the previous ten …