The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

TH Karlsen, N Sheron, S Zelber-Sagi, P Carrieri… - The Lancet, 2022 - thelancet.com
Executive summary Liver diseases have become a major health threat across Europe, and
the face of European hepatology is changing due to the cure of viral hepatitis C and the …

Impact of non-invasive biomarkers on hepatology practice: past, present and future

QM Anstee, L Castera, R Loomba - Journal of hepatology, 2022 - Elsevier
Over the last two decades, there have been tremendous advances in the non-invasive
diagnosis and risk stratification of chronic liver diseases (CLDs). Non-invasive approaches …

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis–2021 update

CPG Panel, A Berzigotti, E Tsochatzis, J Boursier… - Journal of …, 2021 - Elsevier
Non-invasive tests are increasingly being used to improve the diagnosis and
prognostication of chronic liver diseases across aetiologies. Herein, we provide the latest …

[HTML][HTML] Low accuracy of FIB-4 and NAFLD fibrosis scores for screening for liver fibrosis in the population

I Graupera, M Thiele, M Serra-Burriel… - Clinical …, 2022 - Elsevier
Background & Aims Fibrosis-4 (FIB-4) and the nonalcoholic fatty liver disease fibrosis score
(NFS) are the 2 most popular noninvasive blood-based serum tests proposed for …

[PDF][PDF] Population screening for liver fibrosis: toward early diagnosis and intervention for chronic liver diseases

P Ginès, L Castera, F Lammert, I Graupera… - …, 2022 - Wiley Online Library
Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation
triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non‐alcoholic …

Healthcare and socioeconomic costs of NAFLD: A global framework to navigate the uncertainties

AM Allen, JV Lazarus, ZM Younossi - Journal of hepatology, 2023 - Elsevier
Left unaddressed, non-alcoholic fatty liver disease (NAFLD) will continue to have substantial
health, economic and social implications. To address the challenge, a paradigm shift is …

Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study

M Serra-Burriel, A Juanola, F Serra-Burriel, M Thiele… - The Lancet, 2023 - thelancet.com
Background Liver cirrhosis is a major cause of death worldwide. Cirrhosis develops after a
long asymptomatic period of fibrosis progression, with the diagnosis frequently occurring …

Liver biopsy-based validation, confirmation and comparison of the diagnostic performance of established and novel non-invasive steatotic liver disease indexes …

M Kouvari, L Valenzuela-Vallejo, V Guatibonza-Garcia… - Metabolism, 2023 - Elsevier
Background Non-invasive tools (NIT) for metabolic-dysfunction associated liver disease
(MASLD) screening or diagnosis need to be thoroughly validated using liver biopsies …

Alcohol-related liver disease: basic mechanisms and clinical perspectives

SY Liu, IT Tsai, YC Hsu - International journal of molecular sciences, 2021 - mdpi.com
Alcohol-related liver disease (ALD) refers to the liver damage occurring due to excessive
alcohol consumption and involves a broad spectrum of diseases that includes liver steatosis …

Reducing the global burden of alcohol‐associated liver disease: a blueprint for action

SK Asrani, J Mellinger, JP Arab, VH Shah - Hepatology, 2021 - Wiley Online Library
Alcohol‐associated liver disease (ALD) is a major driver of global liver related morbidity and
mortality. There are 2.4 billion drinkers (950 million heavy drinkers) and the lifetime …