Oxidative stress is considered to be involved in the pathophysiology of all cancers. In order
to evaluate the total oxidant/antioxidant status in patients with thyroid cancer and to …

Primary adrenal Cushing syndrome is the result of cortisol hypersecretion mainly by
adenomas and, rarely, by bilateral micronodular or macronodular adrenocortical …

Stratakis CA, Tichomirowa MA, Boikos S, Azevedo MF, Lodish M, Martari M, Verma S, Daly
AF, Raygada M, Keil MF, Papademetriou J, Drori‐Herishanu L, Horvath A, Tsang KM …

Context: The two main subtypes of pseudohypoparathyroidism (PHP), PHP-Ia and-Ib, are
caused by mutations in GNAS exons 1-13 and methylation defects in the imprinted GNAS …

Context Alterations in the cAMP signaling pathway are common in hormonally active
endocrine tumors. Somatic mutations at GNAS are causative in 30–40% of GH-secreting …

Somatostatin analogs currently used in the treatment of acromegaly and other
neuroendocrine tumors inhibit hormone secretion and cell proliferation by binding to …

Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been linked
to predisposition to pituitary adenomas. However, the mechanism by which this occurs …

Background: Fibrolamellar hepatocellular carcinoma (FL-HCC) affects children without
underlying liver disease. A consistent mutation in FL-HCCs leads to fusion of the genes …

Protein Kinase A is an evolutionarily-conserved protein which has been studied in model
organisms from yeast to man. Although the cAMP-PKA signaling system was the first …

Proper regulation of the cAMP‐dependent protein kinase (protein kinase A, PKA) is
necessary for cellular homeostasis, and dysregulation of this kinase is crucial in human …