Cell migration requires sustained forward movement of the plasma membrane at the cell's
front or" leading edge." To date, researchers have uncovered four distinct ways of extending …

For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …

Summary Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that
nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Cell migration is an essential feature of eukaryotic life, required for processes ranging from
feeding and phagoctyosis to development, healing, and immunity. Migration requires the …

The polo family serine threonine kinase Plk4 has been proposed as a therapeutic target in
advanced cancers based on increased expression in primary human cancers, facilitation of …

The Arp2/3 complex has so far been considered to be a single seven-subunit protein
complex required for actin nucleation and actin filament polymerization in diverse critical …

The endothelial barrier of the vasculature is of utmost importance for separating the blood
stream from underlying tissues. This barrier is formed by tight and adherens junctions (TJ …

Epigenetic disorder mechanisms are one of the causes of cancer. The most important of
these changes is the DNA methylation, which leads to the spread of Helicobacter pylori and …

Exocytosis is a fundamental membrane trafficking event in eukaryotic cells in which
membrane proteins or lipids are incorporated into the plasma membrane and vesicle …