Neutrophil migration and its role during inflammation has been the focus of increased
interest in the past decade. Advances in live imaging and the use of new model systems …

Neutrophil migration to injured and pathogen-infected tissues is a fundamental component
of innate immunity. An array of cellular and molecular events mediate this response to …

Neutrophils play a pivotal role in the innate immune response. The small cytokine CXCL8
(also known as IL-8) is known to be one of the most potent chemoattractant molecules that …

Neutrophils are the first immune cells recruited to a site of injury or infection, where they
perform many functions. Having completed their role, neutrophils must be removed from the …

Diseases of failed inflammation resolution are common and largely incurable. Therapeutic
induction of inflammation resolution is an attractive strategy to bring about healing without …

Tissue damage induces early recruitment of neutrophils through redox-regulated Src family
kinase (SFK) signaling in neutrophils. Redox-SFK signaling in epithelium is also necessary …

Immune cells congregate at specific loci to fight infections during inflammatory responses, a
process that must be transient and self-resolving. Cell dispersal promotes resolution, but it …

Stimulation of neutrophil reverse migration presents an attractive, alternative therapeutic
pathway to driving inflammation resolution. However, little is known about whether the …

ABSTRACT A low level of tissue oxygen (hypoxia) is a physiological feature of a wide range
of diseases, from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive …

Neutrophils and macrophages are crucial effectors and modulators of repair and
regeneration following myocardial infarction, but they cannot be easily observed in vivo in …