Therapeutic vaccines for tuberculosis: an overview
R Bouzeyen, B Javid - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis is the world's deadliest bacterial
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …
The immunological life cycle of tuberculosis
JD Ernst - Nature Reviews Immunology, 2012 - nature.com
Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the
bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M …
bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M …
NIR‐II AIE Luminogen‐Based Erythrocyte‐Like Nanoparticles with Granuloma‐Targeting and Self‐Oxygenation Characteristics for Combined Phototherapy of …
H Wang, B Li, Y Sun, Q Ma, Y Feng, Y Jia… - Advanced …, 2024 - Wiley Online Library
Tuberculosis, a fatal infectious disease caused by Mycobacterium tuberculosis (M. tb), is
difficult to treat with antibiotics due to drug resistance and short drug half‐life. Phototherapy …
difficult to treat with antibiotics due to drug resistance and short drug half‐life. Phototherapy …
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent …
S Sakai, KD Kauffman, MA Sallin, AH Sharpe… - PLoS …, 2016 - journals.plos.org
IFN-γ–producing CD4 T cells are required for protection against Mycobacterium tuberculosis
(Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated …
(Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated …
Next-generation TB vaccines: progress, challenges, and prospects
L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …
infectious disease and a leading cause of mortality worldwide. Currently, the only available …
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …
Use of defined TLR ligands as adjuvants within human vaccines
MS Duthie, HP Windish, CB Fox… - Immunological …, 2011 - Wiley Online Library
Our improved understanding of how innate immune responses can be initiated and how
they can shape adaptive B‐and T‐cell responses is having a significant impact on vaccine …
they can shape adaptive B‐and T‐cell responses is having a significant impact on vaccine …
The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial
RN Coler, TA Day, R Ellis, FM Piazza, AM Beckmann… - npj Vaccines, 2018 - nature.com
Tuberculosis (TB) is the leading cause of infectious death worldwide. Development of
improved TB vaccines that boost or replace BCG is a major global health goal. ID93+ GLA …
improved TB vaccines that boost or replace BCG is a major global health goal. ID93+ GLA …
Targeting innate immunity for tuberculosis vaccination
Vaccine development against tuberculosis (TB) is based on the induction of adaptive
immune responses endowed with long-term memory against mycobacterial antigens …
immune responses endowed with long-term memory against mycobacterial antigens …
[HTML][HTML] Novel approaches to tuberculosis vaccine development
SHE Kaufmann, J Weiner, CF von Reyn - International Journal of Infectious …, 2017 - Elsevier
Tuberculosis (TB) remains the deadliest infectious disease. The widely used bacille
Calmette–Guérin (BCG) vaccine offers only limited protection against TB. New vaccine …
Calmette–Guérin (BCG) vaccine offers only limited protection against TB. New vaccine …