A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …

PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2
family member and a critical mediator of p53-dependent and-independent apoptosis …

Apoptosis induced by p53 is firmly established as a central mechanism of tumour
suppression. In addition to its complex functions as a nuclear transcription factor, p53 can …

Nutlin-3 is a small molecule inhibitor of the MDM2/p53 interaction, which leads to the non-
genotoxic p53 stabilization, activation of cell cycle arrest and apoptosis pathways. A series …

Kinase inhibitors targeting the B-cell receptor (BCR) are now prominent in the treatment of
chronic lymphocytic leukemia (CLL). We have focused here on interleukin 4 (IL-4), a …

The tumor suppressor p53 is a transcription factor that in response to a plethora of stress
stimuli activates a complex and context-dependent cellular response ultimately protecting …

Abstract p53 is a powerful tumor suppressor and is an attractive cancer therapeutic target. A
breakthrough in cancer research came from the discovery of the drugs which are capable of …

Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the
cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the …

The pro-survival Bcl-2 family member Mcl-1 is expressed in chronic lymphocytic leukaemia
(CLL), with high expression correlated with progressive disease. The spliceosome inhibitor …

Background Preeclampsia (PE) is characterized by exaggerated apoptosis of the villous
trophoblast of placental villi. Since p53 is a critical regulator of apoptosis we hypothesized …