Recent progress in development of siRNA delivery vehicles for cancer therapy
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …
Current development of siRNA bioconjugates: from research to the clinic
IV Chernikov, VV Vlassov… - Frontiers in …, 2019 - frontiersin.org
Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to
recognize a homologous mRNA sequence in the cell and induce its degradation. The main …
recognize a homologous mRNA sequence in the cell and induce its degradation. The main …
Designing chemically modified oligonucleotides for targeted gene silencing
GF Deleavey, MJ Damha - Chemistry & biology, 2012 - cell.com
Oligonucleotides (ONs), and their chemically modified mimics, are now routinely used in the
laboratory as a means to control the expression of fundamentally interesting or …
laboratory as a means to control the expression of fundamentally interesting or …
Journey of siRNA: clinical developments and targeted delivery
RR Nikam, KR Gore - Nucleic acid therapeutics, 2018 - liebertpub.com
Since the evolutionary discovery of RNA interference and its utilization for gene knockdown
in mammalian cell, a remarkable progress has been achieved in small interfering RNA …
in mammalian cell, a remarkable progress has been achieved in small interfering RNA …
Chemical Modification of siRNAs for In Vivo Use
MA Behlke - Oligonucleotides, 2008 - liebertpub.com
Well over a hundred reports have been published describing use of synthetic small-
interfering RNAs (siRNAs) in animals. The majority of these reports employed unmodified …
interfering RNAs (siRNAs) in animals. The majority of these reports employed unmodified …
Chemically modified siRNA: tools and applications
Chemical modification provides solutions to many of the challenges facing siRNA
therapeutics. This review examines the various siRNA modifications available, including …
therapeutics. This review examines the various siRNA modifications available, including …
Action and reaction: the biological response to siRNA and its delivery vehicles
RNA interference (RNAi)-based therapeutics have significant potential for the treatment of
human disease. Safe and effective delivery of RNA to target tissues remains a major barrier …
human disease. Safe and effective delivery of RNA to target tissues remains a major barrier …
Lung delivery studies using siRNA conjugated to TAT (48− 60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity
The therapeutic application of siRNA shows promise as an alternative approach to small-
molecule inhibitors for the treatment of human disease. However, the major obstacle to its …
molecule inhibitors for the treatment of human disease. However, the major obstacle to its …
Progress toward in vivo use of siRNAs-II
GR Rettig, MA Behlke - Molecular therapy, 2012 - cell.com
RNA interference (RNAi) has been extensively employed for in vivo research since its use
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …
was first demonstrated in mammalian cells 10 years ago. Design rules have improved, and it …
Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers
V Köberle, T Pleli, C Schmithals, E Augusto Alonso… - PloS one, 2013 - journals.plos.org
Background MicroRNAs circulating in the blood, stabilized by complexation with proteins
and/or additionally by encapsulation in lipid vesicles, are currently being evaluated as …
and/or additionally by encapsulation in lipid vesicles, are currently being evaluated as …