Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and affects
millions of individuals globally. AD is associated with cognitive decline and memory loss that …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

Summary Neuraminidase 1 (NEU1) cleaves terminal sialic acids from sialoglycoproteins in
endolysosomes and at the plasma membrane. As such, NEU1 regulates immune cells …

Physiological roles of Cl−, a major anion in the body, are not well known compared with
those of cations. This review article introduces:(1) roles of Cl− in bodily and cellular …

The interaction between metabolic dysfunction and inflammation is central to the
development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's …

Background The global demographic shift towards an aging population is generating a rise
in neurodegenerative conditions, with Alzheimer's disease (AD) as the most prominent …

Tumor necrosis factor receptors (TNFR1 and TNFR2) play key roles in mediating
inflammatory response and cell death signaling, which are associated with autoimmune …

Lysosomes are important cellular structures for human health as centers for recycling,
signaling, metabolism and stress adaptation. However, the potential role of lysosomes in …

The endolysosomal system specializes in degrading cellular components and is crucial to
maintaining homeostasis and adapting rapidly to metabolic and environmental cues. Cells …