Noise—random disturbances of signals—poses a fundamental problem for information
processing and affects all aspects of nervous-system function. However, the nature, amount …

Brains are composed of networks of an enormous number of neurons interconnected with
synapses. Neural information is carried by the electrical signals within neurons and the …

Information processing is energetically expensive. In the mammalian brain, it is unclear how
information coding and energy use are regulated during food scarcity. Using whole-cell …

The ability of cortical neurons to perform temporally accurate computations has been shown
to be important for encoding of information in the cortex; however, cortical neurons are …

The action potential (AP) is transmitted by the concerted action of voltage-gated ion
channels. Thermodynamic fluctuations in channel proteins produce probabilistic gating …

Neurones generate intrinsic subthreshold membrane potential oscillations (MPOs) under
various physiological and behavioural conditions. These oscillations influence neural …

For decades, clinical treatment of depression has usually involved antidepressants that
target noradrenergic and serotonergic neurotransmission. Over the past half century, no …

Maintaining the ability of the nervous system to perceive, remember, process, and react to
the outside world requires a continuous energy supply. Yet the overall power consumption is …

Neurones are noisy elements. Noise arises from both intrinsic and extrinsic sources, and
manifests itself as fluctuations in the membrane potential. These fluctuations limit the …

In this paper we establish limit theorems for a class of stochastic hybrid systems (continuous
deterministic dynamics coupled with jump Markov processes) in the fluid limit (small jumps …