Understanding the impact of antibiotic perturbation on the human microbiome

DJ Schwartz, AE Langdon, G Dantas - Genome medicine, 2020 - Springer
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses
that performs essential functions for immune development, pathogen colonization …

Novel antimicrobial agents for combating antibiotic-resistant bacteria

RYK Chang, SC Nang, HK Chan, J Li - Advanced drug delivery reviews, 2022 - Elsevier
Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome

W Zheng, S Zhao, Y Yin, H Zhang, DM Needham… - Science, 2022 - science.org
Characterizing complex microbial communities with single-cell resolution has been a long-
standing goal of microbiology. We present Microbe-seq, a high-throughput method that …

Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application

KM Danis-Wlodarczyk, DJ Wozniak, ST Abedon - Antibiotics, 2021 - mdpi.com
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

Strategies to combat multidrug-resistant and persistent infectious diseases

O Pacios, L Blasco, I Bleriot, L Fernandez-Garcia… - Antibiotics, 2020 - mdpi.com
Antibiotic failure is one of the most worrying health problems worldwide. We are currently
facing an international crisis with several problematic facets: new antibiotics are no longer …

Therapeutic modulation of fish gut microbiota, a feasible strategy for aquaculture?

F Vargas-Albores, LR Martínez-Córdova… - Aquaculture, 2021 - Elsevier
The intestinal epithelium of fish is the major absorptive barrier for nutrients assisted by a
large number of microbes. These are known as resident microbiota or gut microbiota, which …

Restoration of dysbiotic human gut microbiome for homeostasis

K Dixit, D Chaudhari, D Dhotre, Y Shouche, S Saroj - Life sciences, 2021 - Elsevier
The human microbiome is a complex and dynamic ecosystem, and the imbalance of its
microbial community structure from the normal state is termed dysbiosis. The dysbiotic gut …

[HTML][HTML] Preclinical data and safety assessment of phage therapy in humans

JY Nale, MRJ Clokie - Current opinion in biotechnology, 2021 - Elsevier
Highlights•Phages kill antibiotic resistant/sensitive bacteria so are promising
therapeutics.•Safety and efficacy phage data is needed to motivate clinical trials.•Careful in …

Microbiome dysbiosis: a pathological mechanism at the intersection of obesity and glaucoma

S Pezzino, M Sofia, LP Greco, G Litrico… - International Journal of …, 2023 - mdpi.com
The rate at which obesity is becoming an epidemic in many countries is alarming. Obese
individuals have a high risk of developing elevated intraocular pressure and glaucoma …

An Optimized Bacteriophage Cocktail Can Effectively Control Salmonella in vitro and in Galleria mellonella

JY Nale, GK Vinner, VC Lopez, AM Thanki… - Frontiers in …, 2021 - frontiersin.org
Salmonella spp. is a leading cause of gastrointestinal enteritis in humans where it is largely
contracted via contaminated poultry and pork. Phages can be used to control Salmonella …