The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) targets a number
of Ca2+ homeostatic proteins and regulates gene transcription. Many of the substrates …

This review discusses the structure and properties of the isolated components of troponin,
their interaction, and the mechanisms of regulation of contractile activity of skeletal and …

To elucidate the physiological role of the AMP-adenosine metabolic cycle and to investigate
the relation between AMP and adenosine formation, the O2 supply of isolated guinea pig …

Adenosine is a local hormone, with numerous tissue‐specific biological functions. In the
myocardium, adenosine is released in small amounts at constant basal rate during …

In cardiac muscle, the sarcolemmal sodium/potassium ATPase is the principal quantitative
means of active transport at the myocyte cell surface, and its activity is essential for …

Protein phosphorylation acts a pivotal mechanism in regulating the contractile state of the
heart by modulating particular levels of autonomic control on cardiac force/length …

Previous studies have shown that high-level (300-fold normal) cardiac overexpression of A1-
adenosine receptors (A1-ARs) in transgenic (TG) mice protects isolated hearts against …

The Brugada syndrome (BrS) is characterized by coved-type ST-segment elevation in the
right precordial leads on the electrocardiogram (ECG) and increased risk of sudden cardiac …

Background Autonomic nerve activity is important in the mechanisms of paroxysmal atrial
fibrillation (PAF). Objective The purpose of this study was to test the hypothesis that a single …

Previous reports have demonstrated that the phospholemman (PLM), a 72-residue plasma-
membrane protein enriched in skeletal muscle and heart, is a major substrate …